These problems are not new
From a paper published in 1945 by Vannevar Bush, head of the U.S. Office of Scientific Research and Development (OSRD) during World War II:
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From a paper published in 1945 by Vannevar Bush, head of the U.S. Office of Scientific Research and Development (OSRD) during World War II:
A colleague referenced this 2010 paper which measures proportion of positive results by scientific discipline.
An opinion article from Iain Chalmers (of the very well regarded though not fully open access Cochrane Collaboration) and Paul Glasziou (of the Center for Evidence-based Medicine) discusses the high potential for waste in much research.
An interesting article from Accident Analysis and Prevention from 2004 goes over three case studies where Null Hypothesis Significance Testing may have cost lives.
Found this interesting paper from a couple years ago: Detecting and Correcting the Lies that Data Tellby F Schmidt.
A new PLoS Medicine report investigated how pharmaceutical promotions and advertising influence prescriptions:
“A Systematic Review and Meta-Analysis of Survey Data”
Why Most Published Research Findings Are False
Contradicted and Initially Stronger Effects in Highly Cited Clinical Research